Phytoestrogen Concentrations in Serum from Japanese Men and Women over Forty Years of Age

Asian individuals have much lower incidences of prostate and breast cancer than populations from Western developed countries. They also consume a lower fat, higher fiber diet, with a large intake of phytoestrogens. These phytoestrogens may protect against hormone-dependent cancers and other diseases...

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Published in:	The Journal of nutrition 2002-10, Vol.132 (10), p.3168-3171
Main Authors:	Morton, Michael S., Arisaka, Osamu, Miyake, Noriko, Morgan, Liam D., Evans, Bronwen A.J.
Format:	Article
Language:	eng
Subjects:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - blood Adult Aged Aged, 80 and over Biological and medical sciences breast neoplasms Breast Neoplasms - blood Breast Neoplasms - epidemiology Breast Neoplasms - prevention & control Chromans - blood daidzein developed countries Diet Equol Estrogens Estrogens, Non-Steroidal - administration & dosage Estrogens, Non-Steroidal - blood Female gas chromatography Gas Chromatography-Mass Spectrometry genistein Genistein - blood Human physiology applied to population studies and life conditions. Human ecophysiology Humans Isoflavones - blood Japan Japanese Lignans - blood Male mass spectrometry Medical sciences Men Middle Aged Nutritional survey. Food supply and nutritional requirement Phytoestrogens plant estrogens Plant Preparations Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Prostatic Neoplasms - prevention & control serum soy Soy products United Kingdom Women
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Summary:	Asian individuals have much lower incidences of prostate and breast cancer than populations from Western developed countries. They also consume a lower fat, higher fiber diet, with a large intake of phytoestrogens. These phytoestrogens may protect against hormone-dependent cancers and other diseases. Our study used established gas chromatography-mass spectrometry (GC-MS) methodologies to measure the concentrations of four phytoestrogens (daidzein, genistein, equol and enterolactone) in serum samples obtained from Japanese men (n = 102) and women (n = 125) > 40 y old. The results were compared with those obtained with samples from the UK. The Japanese men and women had higher (P < 0.001) concentrations of circulating daidzein, genistein and equol than individuals from the UK. The mean concentration of genistein in Japanese men, for example, was 492.7 nmol/L, compared with 33.2 nmol/L in men from the UK. The two populations, however, had similar serum concentrations of enterolactone. Furthermore, 58% of the Japanese men and 38% of the Japanese women had equol concentrations > 20 nmol/L, compared with none of the UK men and 2.2% of the UK women. These results support previously published GC-MS results from studies with low numbers of samples.
ISSN:	0022-3166 1541-6100