Detection of HTLV-I antigen in peripheral and cord blood lymphocytes from carrier mothers

Vertical transmission of human T-cell lymphotropic virus type-I (HTLV-I) from an antibody-positive carrier mother to her infant has been reported, but it is not clear when and by what route such transmission occurs. Peripheral blood and cord blood lymphocytes from 40 antibody-positive carrier mother...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-10, Vol.338 (8772), p.915-916
Main Authors: Satow, Y., Hashido, M., Honda, H., Mizuno, M., Kawana, T., Ishikawa, K., Hayami, M.
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Antigens
Biological and medical sciences
Blood
Breast Feeding
Carrier State - immunology
Cord blood
Female
Fetal Blood - immunology
Fetal Blood - microbiology
HTLV-I Antigens - blood
HTLV-I Infections - immunology
HTLV-I Infections - transmission
Human viral diseases
Humans
Immunofluorescence
Infant
Infant, Newborn
Infections
Infectious diseases
Leukemia
Lymphocytes
Lymphocytes - immunology
Lymphocytes - microbiology
Lymphocytes T
Medical research
Medical sciences
Mothers
Peripheral blood
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - microbiology
Tropical medicine
Viral diseases
Viruses
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Summary:Vertical transmission of human T-cell lymphotropic virus type-I (HTLV-I) from an antibody-positive carrier mother to her infant has been reported, but it is not clear when and by what route such transmission occurs. Peripheral blood and cord blood lymphocytes from 40 antibody-positive carrier mothers were cultured for 2 months and HTLV-I antigen was sought by indirect immunofluorescence. Viral antigen was detected in 28 (70%) samples of peripheral blood lymphocytes and in 2 of cord blood lymphocytes, both from mothers positive for antigen in peripheral blood. From these data it is estimated that transplacental infection occurs at a rate of about 7%.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)91775-P