Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder

OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy...

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Bibliographic Details
Published in:The American journal of psychiatry 2002-10, Vol.159 (10), p.1785-1787
Main Authors: Woo, Jong-Min, Yoon, Kyung-Sik, Yu, Bum-Hee
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age of Onset
Agoraphobia - diagnosis
Agoraphobia - genetics
Anxiety disorders. Neuroses
Biological and medical sciences
Catechol O-Methyltransferase - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genotype
Humans
Korea - epidemiology
Male
Medical sciences
Panic disorder
Panic Disorder - diagnosis
Panic Disorder - epidemiology
Panic Disorder - genetics
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Treatment Outcome
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Summary:OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. RESULTS: The frequency of the L L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L L genotype. Patients with panic disorder who had the L L genotype showed poorer treatment response than those with other genotypes. CONCLUSIONS: These results suggest that the L L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.159.10.1785