Dietary fiber suppresses elevations of uric acid and allantoin in serum and urine induced by dietary RNA and increases its excretion to feces in rats

"This study was performed to examine the effects of several kinds of dietary fibers (DF) with different physical properties on dietary RNA metabolism. Male Wistar strain rats, 4 wk old, were fed diets with or without a 3% yeast RNA and a 5% DF (cellulose, chitin, chitosan, inulin, and xanthan g...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 2002, Vol.48(3), pp.184-193
Main Authors: "Koguchi, T. (Tokyo Univ. of Agriculture (Japan)), Nakajima, H, Wada, M, Yamamoto, Y, Innami, S, Maekawa, A, Tadokoro, T.
Format: Article
Language:English
Subjects:
Adsorption
ALLANTOIN
Allantoin - blood
Allantoin - metabolism
Allantoin - urine
Animals
Biological and medical sciences
BLOOD SERUM
Carbon Radioisotopes
dietary fiber
Dietary Fiber - administration & dosage
Dietary Fiber - pharmacology
DIETARY FIBRES
dietary RNA
Digestion
FAECES
Feces - chemistry
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Jejunum - metabolism
Male
RATS
Rats, Wistar
Ribonucleases - metabolism
RNA
RNA - administration & dosage
RNA - pharmacokinetics
RNA - pharmacology
RNA metabolism
RNase A
serum uric acid concentration
URIC ACID
Uric Acid - blood
Uric Acid - metabolism
Uric Acid - urine
URINE
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Viscosity
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Summary:"This study was performed to examine the effects of several kinds of dietary fibers (DF) with different physical properties on dietary RNA metabolism. Male Wistar strain rats, 4 wk old, were fed diets with or without a 3% yeast RNA and a 5% DF (cellulose, chitin, chitosan, inulin, and xanthan gum) for 20d(Experiment 1) or 5d(Experiment 2). Feeding DF tested lowered the serum uric acid and allantoin concentrations and the urinary excretions of their compounds and increased the amount of RNA excreted into the feces compared with fiber-free. The water-holding capacity and nucleotide adsorption of chitin and chitosan in acidic solutions were higher than those of cellulose. The digestion rate of RNA by RNase A in vitro was found to be lower in the DF tested than in fiber-free. The decrease was remarkable in chitosan and xanthan gum. The uptakes of sup14 C-labeled adenosine and adenosine 5'-monophosphate(5'-AMP) in the rat jejunum were markedly decreased in regard to chitosan and xanthan gum in comparison with the fiber-free. These phenomena suggest that DF with high viscosity is more strongly associated with the suppression of RNA digestion by RNase A and the depression of the uptake of purine compounds to jejunum. The present results reveal that the elevation of serum uric acld concentration induced by dietary RNA can be suppressed by DF in rats."
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.48.184