WNT-3, Expressed by Motoneurons, Regulates Terminal Arborization of Neurotrophin-3-Responsive Spinal Sensory Neurons

Sensory axons from dorsal root ganglia neurons are guided to spinal targets by molecules differentially expressed along the dorso-ventral axis of the neural tube. NT-3-responsive muscle afferents project ventrally, cease extending, and branch upon contact with motoneurons (MNs), their synaptic partn...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2002-09, Vol.35 (6), p.1043-1056
Main Authors: Krylova, Olga, Herreros, Judit, Cleverley, Karen E, Ehler, Elisabeth, Henriquez, Juan Pablo, Hughes, Simon M, Salinas, Patricia C
Format: Article
Language:English
Subjects:
Afferent Pathways - cytology
Afferent Pathways - embryology
Afferent Pathways - metabolism
Animals
Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Cell Differentiation - drug effects
Cell Differentiation - genetics
Cells, Cultured
Ganglia, Spinal - cytology
Ganglia, Spinal - embryology
Ganglia, Spinal - metabolism
Glycogen Synthase Kinase 3
Glycoproteins - metabolism
Glycoproteins - pharmacology
Growth Cones - drug effects
Growth Cones - metabolism
Growth Cones - ultrastructure
Intracellular Signaling Peptides and Proteins
Mice
Motor Neurons - cytology
Motor Neurons - metabolism
Nerve Growth Factor - metabolism
Nerve Growth Factor - pharmacology
Neural Pathways - cytology
Neural Pathways - embryology
Neural Pathways - metabolism
Neuronal Plasticity - drug effects
Neuronal Plasticity - genetics
Neurons
Neurons, Afferent - cytology
Neurons, Afferent - drug effects
Neurons, Afferent - metabolism
Neurosciences
Neurotrophin 3 - metabolism
Neurotrophin 3 - pharmacology
Presynaptic Terminals - drug effects
Presynaptic Terminals - metabolism
Presynaptic Terminals - ultrastructure
Proteins
Proteins - antagonists & inhibitors
Proteins - genetics
Proteins - metabolism
Signal Transduction - drug effects
Signal Transduction - genetics
Spinal cord
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - metabolism
Statistical analysis
Wnt Proteins
Wnt3 Protein
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Summary:Sensory axons from dorsal root ganglia neurons are guided to spinal targets by molecules differentially expressed along the dorso-ventral axis of the neural tube. NT-3-responsive muscle afferents project ventrally, cease extending, and branch upon contact with motoneurons (MNs), their synaptic partners. We have identified WNT-3 as a candidate molecule that regulates this process. Wnt-3 is expressed by MNs of the lateral motor column at the time when MNs form synapses with sensory neurons. WNT-3 increases branching and growth cone size while inhibiting axonal extension in NT-3- but not NGF-responsive axons. Ventral spinal cord secretes factors with axonal remodeling activity for NT-3-responsive neurons. This activity is present at limb levels and is blocked by a WNT antagonist. We propose that WNT-3, expressed by MNs, acts as a retrograde signal that controls terminal arborization of muscle afferents.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)00860-7