BMP Signaling Is Required Locally to Pattern the Dorsal Telencephalic Midline

BMPs have been proposed to pattern the medial-lateral axis of the telencephalon in a concentration-dependent manner, thus helping to subdivide the embryonic telencephalon into distinct forebrain regions. Using a CRE/ loxP genetic approach, we tested this hypothesis by disrupting the Bmpr1a gene in t...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2002-09, Vol.35 (6), p.1029-1041
Main Authors: Hébert, Jean M., Mishina, Yuji, McConnell, Susan K.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Body Patterning - genetics
Bone Morphogenetic Protein Receptors, Type I
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - metabolism
Brain
Cell Differentiation - genetics
Choroid Plexus - cytology
Choroid Plexus - embryology
Choroid Plexus - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Female
Fetus
Forkhead Transcription Factors
Gene Expression Regulation, Developmental - genetics
Integrases - genetics
Integrases - metabolism
Ligands
Medical research
Mice
Mice, Knockout
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neurons - cytology
Neurons - metabolism
Pregnancy
Protein-Serine-Threonine Kinases
Receptors, Growth Factor
Receptors, Transforming Growth Factor beta - deficiency
Receptors, Transforming Growth Factor beta - genetics
Signal Transduction - genetics
Stem Cells - cytology
Stem Cells - metabolism
Telencephalon - cytology
Telencephalon - embryology
Telencephalon - metabolism
Viral Proteins - genetics
Viral Proteins - metabolism
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Summary:BMPs have been proposed to pattern the medial-lateral axis of the telencephalon in a concentration-dependent manner, thus helping to subdivide the embryonic telencephalon into distinct forebrain regions. Using a CRE/ loxP genetic approach, we tested this hypothesis by disrupting the Bmpr1a gene in the telencephalon. In mutants, BMP signaling was compromised throughout the dorsal telencephalon, but only the most dorsalmedial derivative, the choroid plexus, failed to be specified or differentiate. Choroid plexus precursors remained proliferative and did not adopt the fate of their lateral telencephalic neighbors. These results demonstrate that BMP signaling is required for the formation of the most dorsal telencephalic derivative, the choroid plexus, and that BMP signaling plays an essential role in locally patterning the dorsal midline. Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)00900-5