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Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors
Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein...
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| Published in: | Immunogenetics (New York) 2002-09, Vol.54 (6), p.394-402 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 402 |
| container_issue | 6 |
| container_start_page | 394 |
| container_title | Immunogenetics (New York) |
| container_volume | 54 |
| creator | Tovar, Victoria del Valle, Juana Zapater, Nuria Martin, Margarita Romero, Xavier Pizcueta, Pilar Bosch, Jaime Terhorst, Cox Engel, Pablo |
| description | Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two extracellular immunoglobulin-like domains, a transmembrane region and an 88-amino acid cytoplasmic domain. Mouse novel Ly9 is structurally similar to the extracellular domains of CD84 and CD229 (Ly9). Both mouse and human novel Ly9 genes mapped close to the CD229gene in a region where other members of the CD150 family have also been mapped, and analysis of their genomic sequences showed that they have an identical intron/exon organization. Northern blot analysis revealed that the expression of mouse and human novel Ly9 was predominantly restricted to hematopoietic tissues, with the exception of testis. Here we show that SAP (SH2D1A), an adapter protein responsible for the X-linked lymphoproliferative disease, binds to the phosphorylated cytoplasmic tail of human but not mouse novel Ly9. Taken together, these data indicate that mouse novel Ly9 is a new member of the expanding CD150 family of cell surface receptors. |
| doi_str_mv | 10.1007/s00251-002-0483-3 |
| format | article |
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| source | Springer Nature |
| subjects | Amino Acid Sequence Animals Antigens, CD - genetics Antigens, CD - metabolism Base Sequence Carrier Proteins - metabolism Chromosome Mapping Cloning, Molecular DNA, Complementary - genetics Female Gene Expression Glycoproteins - genetics Glycoproteins - metabolism Humans Immunoglobulins - genetics Immunoglobulins - metabolism Intracellular Signaling Peptides and Proteins Leukocytes - immunology Male Mice Molecular Sequence Data Pregnancy Receptors, Cell Surface Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid Signaling Lymphocytic Activation Molecule Associated Protein Signaling Lymphocytic Activation Molecule Family Signaling Lymphocytic Activation Molecule Family Member 1 Species Specificity Tissue Distribution |
| title | Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors |
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