Plasma growth hormone-binding activity is low in uraemic children

Plasma growth hormone-binding protein (GH-BP) activity was evaluated in two groups of prepubertal children with chronic renal failure (CRF) who had been treated with recombinant human GH (rhGH). Group 1 consisted of eight children (mean chronological age 10.8 years) with advanced renal failure; grou...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1991-07, Vol.5 (4), p.545-547
Main Authors: POSTEL-VINAY, M. C, TAR, A, CROSNIER, H, BROYER, M, RAPPAPORT, R, TONSHOFF, B, MEHLS, O
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carrier Proteins - blood
Child
Child, Preschool
Chromatography, High Pressure Liquid
Female
Growth Disorders - drug therapy
Growth Hormone - metabolism
Growth Hormone - therapeutic use
Hormones. Endocrine system
Humans
Kidney Failure, Chronic - blood
Male
Medical sciences
Pharmacology. Drug treatments
Premedication
Recombinant Proteins - therapeutic use
Uremia - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasma growth hormone-binding protein (GH-BP) activity was evaluated in two groups of prepubertal children with chronic renal failure (CRF) who had been treated with recombinant human GH (rhGH). Group 1 consisted of eight children (mean chronological age 10.8 years) with advanced renal failure; group 2 consisted of nine children (mean chronological age 6 years) presenting with end-stage renal disease, who were on dialysis. Before treatment the specific binding of (125I)hGH to high-affinity GH-BP was low in the two groups (group 1, 17.3 +/- 1.6% of radioactivity; group 2, 14.2 +/- 1.4%) compared with the mean value obtained in normal prepubertal children (24.8 +/- 1.7%). No significant changes in GH-BP activity were found during the 1st year of GH therapy, although growth velocity and plasma levels of insulin-like growth factor-I increased significantly in both groups. The low GH-binding activity found in children with CRF supports the state of GH resistance. The reason for the absence of a GH-BP response to GH therapy has to be clarified.
ISSN:0931-041X
1432-198X
DOI:10.1007/bf01453698