Rapid signal transduction in Sertoli cells

The importance of non-genomic signaling as a complementary route for cell regulation has recently become evident. This rapid mechanism is utilized not just by peptide hormones, but also by steroids and other lipid-related substances, resulting in amplification and fine-tuning of the signals. The Ser...

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Bibliographic Details
Published in:European journal of endocrinology 2002-09, Vol.147 (3), p.425-433
Main Authors: SILVA, Fatima R. M. B, LEITE, Laura D, WASSERMANN, Guillermo F
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcitriol - physiology
Follicle Stimulating Hormone - physiology
Fundamental and applied biological sciences. Psychology
Hormone metabolism and regulation
Humans
Male
Mammalian male genital system
Sertoli Cells - metabolism
Signal Transduction
Testosterone - physiology
Triiodothyronine - physiology
Tropical medicine
Vertebrates: reproduction
Vitamin A - physiology
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Summary:The importance of non-genomic signaling as a complementary route for cell regulation has recently become evident. This rapid mechanism is utilized not just by peptide hormones, but also by steroids and other lipid-related substances, resulting in amplification and fine-tuning of the signals. The Sertoli cell is the principal target for hormone action in the seminiferous tubules. The involvement of FSH, testosterone and tri-iodothyronine (T(3)) in the spermatogenetic process is widely known. This paper discusses some rapid responses to FSH, retinol, testosterone and T(3) in the control of Sertoli cell function. Studies employing various methodologies and techniques are described and several hypotheses are considered in an attempt to explain the interactions of hormones with plasma membrane receptors. Recent knowledge about these new signaling mechanisms and cross-talk between them opens new fields of research on the communication and integration of the multiple hormonal signaling systems.
ISSN:0804-4643
1479-683X
DOI:10.1530/eje.0.1470425