Recent advances in cutaneous angiogenesis

Summary An understanding of the molecular basis of angiogenesis is key to the appreciation of many of the advances made in the field of neovascularization over the past two decades. The sequence of events involved in angiogenesis includes: (i) increased vascular permeability and leakage; (ii) degrad...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2002-09, Vol.147 (3), p.418-425
Main Authors: Bhushan, M., Young, H.S., Brenchley, P.E.C., Griffiths, C.E.M.
Format: Article
Language:English
Subjects:
angiogenesis
Angiogenesis Inducing Agents - physiology
Angiogenesis Inhibitors - therapeutic use
angiopoietins
Humans
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - physiopathology
Skin - blood supply
Skin Diseases - drug therapy
Skin Diseases - physiopathology
therapy
thrombospondin
vascular endothelial growth factor
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Summary:Summary An understanding of the molecular basis of angiogenesis is key to the appreciation of many of the advances made in the field of neovascularization over the past two decades. The sequence of events involved in angiogenesis includes: (i) increased vascular permeability and leakage; (ii) degradation of basement membrane; (iii) endothelial cell proliferation and migration through the surrounding extracellular matrix; and (iv) maturation and stabilization of the newly formed vessel bed. This review provides an update on the molecular basis of such pathways in the skin, with particular emphasis on the endothelial cell‐specific vascular endothelial growth factor and angiopoietins as modulators of angiogenesis that can be targeted in therapy of cutaneous disease.
ISSN:0007-0963
1365-2133
DOI:10.1046/j.1365-2133.2002.05003.x