Prediction of Plant MicroRNA Targets

We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterni...

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Bibliographic Details
Published in:Cell 2002-08, Vol.110 (4), p.513-520
Main Authors: Rhoades, Matthew W., Reinhart, Brenda J., Lim, Lee P., Burge, Christopher B., Bartel, Bonnie, Bartel, David P.
Format: Article
Language:English
Subjects:
Arabidopsis - genetics
Arabidopsis - growth & development
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Cell Differentiation - genetics
Cell Division - genetics
Cell Lineage - genetics
Gene Expression Regulation, Developmental - genetics
Gene Expression Regulation, Plant - genetics
Genes, Regulator - genetics
MicroRNAs
Models, Biological
Molecular Sequence Data
Predictive Value of Tests
RNA, Antisense - genetics
RNA, Antisense - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Signal Transduction - genetics
Transcription Factors - genetics
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Summary:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differentiation. The near-perfect complementarity between plant miRNAs and their targets suggests that many plant miRNAs act similarly to small interfering RNAs and direct mRNA cleavage. The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00863-2