Rhinitis increase the risk for adult-onset asthma—a Swedish population-based case-control study (MAP-study)

The aim of the study was to examine certain predictors, especially non-infectious rhinitis, and the risk for adult-onset asthma. A nested case-control study of adult-onset asthma was performed in a random sample from the general population (n=15 813), aged 21 to 51 years. Cases for the study include...

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Bibliographic Details
Published in:Respiratory medicine 2002-08, Vol.96 (8), p.635-641
Main Authors: TORÉN, K., OLIN, A.-C., HELLGREN, J., HERMANSSON, B.-A.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Asthma - etiology
atopy
Biological and medical sciences
Case-Control Studies
Chronic obstructive pulmonary disease, asthma
epidemiology
Female
Humans
Male
Medical sciences
Middle Aged
Odds Ratio
Pneumology
population-based
rhinitis
Rhinitis - complications
Rhinitis - epidemiology
Risk Factors
smoking
Smoking - adverse effects
Smoking - epidemiology
Sweden - epidemiology
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Summary:The aim of the study was to examine certain predictors, especially non-infectious rhinitis, and the risk for adult-onset asthma. A nested case-control study of adult-onset asthma was performed in a random sample from the general population (n=15 813), aged 21 to 51 years. Cases for the study included subjects reporting physician-diagnosed asthma (n=235) and controls (n=2044) were randomly selected from the whole population sample. The case-control sample was investigated with a comprehensive respiratory questionnaire. Odds ratios were calculated stratified for sex, year of diagnosis and birth-year. Adult-onset physician-diagnosed asthma was associated with occurrence of non-infectious rhinitis before asthma onset (OR=5.4, 95% CI 4.0–7.2), especially among smoking non-atopics (OR=9.1, 95% CI 5.3–15.4). Smoking before asthma onset increased the risk for asthma (OR=1.5, 95% CI 1.1–2.1). In conclusion, this population-based case-control study indicate that non-infectious rhinitis and current smoking, especially among non-atopics, are associated with increased risk for adult-onset asthma.
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.2002.1319