Androgen receptor CAG polymorphism and prostate cancer risk

Recent studies have suggested that polymorphisms of the androgen receptor gene ( AR) may influence the risk of prostate cancer (PC) development and progression. Here, we analyzed the length of the CAG repeat of the AR gene in 1363 individuals, including patients with PC, benign prostate hyperplasia...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 2002-08, Vol.111 (2), p.166-171
Main Authors: MONONEN, Nina, IKONEN, Tarja, AUTIO, Ville, RÖKMAN, Annika, MATIKAINEN, Mika P, TAMMELA, Teuvo L. J, KALLIONIEMI, Olli-P, KOIVISTO, Pasi A, SCHLEUTKER, Johanna
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Case-Control Studies
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease-Free Survival
DNA, Neoplasm - analysis
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Molecular and cellular biology
Neoplasm Recurrence, Local - genetics
Neoplasm Staging
Neurology
Polymerase Chain Reaction
Polymorphism, Genetic
Prostatic Hyperplasia - genetics
Prostatic Neoplasms - genetics
Receptors, Androgen - genetics
Risk Factors
Trinucleotide Repeats - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent studies have suggested that polymorphisms of the androgen receptor gene ( AR) may influence the risk of prostate cancer (PC) development and progression. Here, we analyzed the length of the CAG repeat of the AR gene in 1363 individuals, including patients with PC, benign prostate hyperplasia (BPH), and population controls. There was a tendency for short CAG repeats to be associated with PC. The Odds Ratio (OR) for PC was 1.47 ( P=0.05) when individuals with short CAG repeats (18). CAG repeat length was not significantly associated with family history, disease stage, grade, age at diagnosis, prostate-specific antigen (PSA) level at diagnosis, or prognosis of the patients. Unexpectedly, short CAG repeats were significantly less common in patients with BPH compared with controls (OR=0.47, P=0.03). Our results suggest that the CAG polymorphism of the AR gene is unlikely to have a major role in the development or progression of PC in the Finnish population. The association of CAG repeats with the risk of BPH warrants further study.
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-002-0776-5