Health‐related quality of life in juvenile‐onset systemic lupus erythematosus and its relationship to disease activity and damage

Objective To assess the health‐related quality of life (HRQL) of patients with juvenile‐onset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage. Methods In this cross‐sectional study, HRQL was assessed using the Child Health Questionnaire (CHQ), di...

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Published in:Arthritis and rheumatism 2004-06, Vol.51 (3), p.458-464
Main Authors: Ruperto, Nicolino, Buratti, Silvia, Duarte‐Salazar, Carolina, Pistorio, Angela, Reiff, Andreas, Bernstein, Bram, Maldonado‐Velázquez, Maria Rocío, Beristain‐Manterola, Rosalía, Maeno, Nobuaki, Takei, Syuji, Falcini, Fernanda, Lepore, Loredana, Spencer, Charles H., Pratsidou‐Gertsi, Polixeni, Martini, Alberto, Ravelli, Angelo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Arthritis, Juvenile - complications
Arthritis, Juvenile - physiopathology
Arthritis, Juvenile - psychology
Biological and medical sciences
Case-Control Studies
Central Nervous System Diseases - etiology
Cross-Sectional Studies
Disease activity
Diseases of the osteoarticular system
Female
Health Status
Health‐related quality of life
Humans
Kidney Diseases - etiology
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - physiopathology
Lupus Erythematosus, Systemic - psychology
Male
Medical sciences
Musculoskeletal Diseases - etiology
Organ damage
Psychology
Quality of Life
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Surveys and Questionnaires
Systemic lupus erythematosus
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Summary:Objective To assess the health‐related quality of life (HRQL) of patients with juvenile‐onset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage. Methods In this cross‐sectional study, HRQL was assessed using the Child Health Questionnaire (CHQ), disease activity using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and accumulated damage using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Results A total of 297 patients were included. The mean ± SD physical and psychosocial summary scores of the CHQ were 40.2 ± 15.0 and 44.8 ± 10.7, respectively. The most impaired CHQ subscales were global health, general health perceptions, and parent impact–emotional. The SLEDAI score was significantly correlated with both the physical summary score (r = −0.29, P < 0.0001) and psychosocial summary score (r = −0.25, P < 0.0001), whereas the SDI score was significantly correlated only with the physical summary score (r = −0.23, P = 0.0001). Conclusion We found that patients with JSLE have significant impairment of their HRQL, particularly in the physical domain. HRQL may be affected by both disease activity and accumulated damage, particularly in the renal, central nervous, and musculoskeletal systems.
ISSN:0004-3591
0893-7524
1529-0131
1529-0123
DOI:10.1002/art.20412