Human Leukocyte Antigens and Prognosis in Patients With Head and Neck Cancer: Results of a Prospective Follow-up Study

Background Prognostic information is essential for optimal treatment of patients with head and neck cancer. We studied the relationship of class I and class II human leukocyte antigens (HLA) on prognosis in patients with head and neck cancer. Methods HLA‐A, ‐B, ‐C and ‐DR antigens were determined in...

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Bibliographic Details
Published in:The Laryngoscope 2002-04, Vol.112 (4), p.651-657
Main Authors: Tisch, M., Kyrberg, H., Weidauer, H., Mytilineos, J., Conradt, C., Opelz, G., Maier, H.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - mortality
Follow-Up Studies
head and neck cancer
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - mortality
HLA Antigens - analysis
HLA-A Antigens - analysis
HLA-A11 Antigen
HLA-antigens
HLA-DR6 Antigen - analysis
Humans
Male
Medical sciences
Middle Aged
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prognosis
Survival Analysis
Survival Rate
Time Factors
Tumors
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Summary:Background Prognostic information is essential for optimal treatment of patients with head and neck cancer. We studied the relationship of class I and class II human leukocyte antigens (HLA) on prognosis in patients with head and neck cancer. Methods HLA‐A, ‐B, ‐C and ‐DR antigens were determined in 209 patients with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. The patients were subjected to follow‐up investigations for a period of 5 years. Results Five‐year survival rates in relation to tumor stage varied between 86% for stage I tumors and 28% for stage IV tumors (P
ISSN:0023-852X
1531-4995
DOI:10.1097/00005537-200204000-00011