Trefoil factor family (TFF) peptides and cancer progression

TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to...

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Bibliographic Details
Published in:Peptides 2004-05, Vol.25 (5), p.885-898
Main Authors: Emami, Shahin, Rodrigues, Sylvie, Rodrigue, Christelle M, Le Floch, Nathalie, Rivat, Christine, Attoub, Samir, Bruyneel, Erik, Gespach, Christian
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
COX-1
COX-2
EGF-R
Humans
Invasion
Neoplasm Invasiveness - pathology
Neoplasms - metabolism
Peptides - metabolism
PI3′-kinase
PLC
RhoAGTPase
Scattering
Signal Transduction - physiology
src
TXA-2-R
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Summary:TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2003.10.019