In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia

Some quassinoids ( 1– 6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities. The most active compound for inhibition of tumor promoter-indu...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2002-09, Vol.82 (1), p.55-58
Main Authors: Jiwajinda, Suratwadee, Santisopasri, Vilai, Murakami, Akira, Kawanaka, Masanori, Kawanaka, Hiromu, Gasquet, Monique, Eilas, Riad, Balansard, Guy, Ohigashi, Hajime
Format: Article
Language:English
Subjects:
Animals
Anti-parasitic activities
Anti-tumor promoting activity
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - pharmacology
Antimalarials - chemistry
Antimalarials - pharmacology
Asia, Southeastern
Biological and medical sciences
Cell Survival - drug effects
Dose-Response Relationship, Drug
Eurycoma - chemistry
Eurycoma longifolia
General pharmacology
Herpesvirus 4, Human - drug effects
Herpesvirus 4, Human - physiology
Humans
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plasmodium falciparum - drug effects
Quassinoid
Quassins - chemistry
Quassins - pharmacology
Schistosomicides - chemistry
Schistosomicides - pharmacology
Simaroubaceae
Tumor Cells, Cultured
Virus Activation - drug effects
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Summary:Some quassinoids ( 1– 6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities. The most active compound for inhibition of tumor promoter-induced Epstein–Barr virus activation (anti-tumor promotion) was 14,15β-dihydroxyklaineanone ( 5, IC 50=5 μM). Longilactone ( 1) gave significant antischistosomal effect at a concentration of 200 μg/ml. 11-Dehydroklaineanone ( 3) and 15β- O-acetyl-14-hydroxyklaineanone ( 6) showed potent plasmodicidal activity (IC 50=2 μg/ml). Thus it was suggested that E. longifolia possesses high medicinal values due to the occurrence of a variety of quassinoids.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(02)00160-5