Extravascular necrotizing palisaded granulomas as the presenting skin sign of systemic lupus erythematosus

Summary We recently examined a patient who presented clinically with tender, erythematous papules associated with a febrile illness and polyarthralgias. Histopathological examination revealed extravascular palisaded neutrophilic granulomas, a skin reaction pattern originally described in Churg–Strau...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2002-08, Vol.147 (2), p.371-374
Main Authors: Obermoser, G., Zelger, B., Zangerle, R., Sepp, N.
Format: Article
Language:English
Subjects:
Adult
Basement Membrane - immunology
Biological and medical sciences
Complement C3 - analysis
extravascular necrotizing palisaded granulomas
Female
Fluorescent Antibody Technique
Granuloma - etiology
Humans
immune complexes
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
systemic lupus erythematosus
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Summary:Summary We recently examined a patient who presented clinically with tender, erythematous papules associated with a febrile illness and polyarthralgias. Histopathological examination revealed extravascular palisaded neutrophilic granulomas, a skin reaction pattern originally described in Churg–Strauss disease but subsequently observed in a variety of other systemic disorders characterized by immune complex generation. A diagnosis of systemic lupus erythematosus (SLE) was established. To our knowledge, this is the first report of extravascular necrotizing palisaded granulomas as the presenting skin sign of SLE.
ISSN:0007-0963
1365-2133
DOI:10.1046/j.1365-2133.2002.04790.x