Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia

The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typi...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2002-05, Vol.96 (3), p.327-328
Main Authors: Aucan, Christophe, Walley, Andrew J., Greenwood, Brian M., Hill, Adrian V.S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case-Control Studies
Gambia
Gene Frequency
gene polymorphisms
Genetic Predisposition to Disease
Genotype
haptoglobin
Haptoglobins - genetics
Human protozoal diseases
Humans
Immunity, Innate - genetics
Infectious diseases
Malaria
Malaria, Falciparum - genetics
Malaria, Falciparum - immunology
Medical sciences
Parasitic diseases
pathogenesis
Plasmodium falciparum
Polymorphism, Genetic
Protozoal diseases
The Gambia
Tropical medicine
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Summary:The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed.
ISSN:0035-9203
1878-3503
DOI:10.1016/S0035-9203(02)90114-8