Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

Behçet’s disease is a multi-system inflammatory disorder of unknown etiology. The disease is more prevalent in Eastern Mediterranean countries and Japan where there is a linkage to HLA-B51. Mexican Mestizos are suitable subjects for studying the role of ethnicity in the susceptibility to Behçet’s di...

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Bibliographic Details
Published in:Immunology letters 2004-05, Vol.93 (2), p.211-215
Main Authors: Soto-Vega, Elena, Garcı́a-Muñoz, Ricardo, Richaud-Patin, Yvonne, Zúñiga-Ramos, Joaquı́n, Crispı́n, José Carlos, Dı́az-Jouanen, Efraı́n, Flores-Suárez, Luis Felipe, Llorente, Luis, Granados, Julio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Behcet Syndrome - ethnology
Behcet Syndrome - genetics
Behçet’s disease
Child
Female
Gene Frequency
Genes, MHC Class I - genetics
Genes, MHC Class II - genetics
Genetic susceptibility
Haplotypes
HLA-B
HLA-B Antigens - genetics
HLA-DR
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Male
Mexican Mestizos
Mexico
Middle Aged
Polymorphism, Genetic - genetics
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Summary:Behçet’s disease is a multi-system inflammatory disorder of unknown etiology. The disease is more prevalent in Eastern Mediterranean countries and Japan where there is a linkage to HLA-B51. Mexican Mestizos are suitable subjects for studying the role of ethnicity in the susceptibility to Behçet’s disease. High-resolution HLA class I and class II typing was performed by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) reverse dot blot and PCR-single-strand polymorphism in 32 patients with Behçet’s disease and 99 healthy ethnically-matched controls. A significant increased frequency of HLA-B *44 ( P=0.02; OR = 2.78; CI 95% = 1.1–7.7), HLA-B *52 ( P=0.02; OR = 5.33; CI 95% = 1.07–29.1), and HLA-B *56 ( P=0.003; OR = 4.19; CI 95% = 3.37–5.21) as well as HLA-DRB1 *01 and HLA-DRB1 *13 ( P=0.007; OR = 3.36; CI 95% = 1.22–9.27) was found in Mexican patients with Behçet’s disease when compared to controls. The low frequency of native markers in Mexican Mestizo patients with Behçet’s disease suggests that genetic admixture between Eastern Mediterraneans and Orientals with Amerindians is a recent event that increased the risk of developing Behçet’s disease in the Mexican population.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2004.03.017