Metabolic characteristics of women who developed ovarian hyperstimulation syndrome

BACKGROUND: The aim of this study was to investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients. Additionally, we also assessed whether any abnormalities in the haemostatic system...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2002-08, Vol.17 (8), p.1994-1996
Main Authors: Delvigne, Annick, Kostyla, Karol, De Leener, Anne, Lejeune, Bernard, Cantiniaux, Brigitte, Bergmann, Pierre, Rozenberg, Serge
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Factor V - genetics
Female
Genetic Predisposition to Disease - genetics
Gynecology. Andrology. Obstetrics
Humans
Hyperinsulinism - etiology
insulin resistance
IVF
Medical sciences
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
ovarian hyperstimulation syndrome (OHSS)
Ovarian Hyperstimulation Syndrome - complications
Ovarian Hyperstimulation Syndrome - genetics
Ovarian Hyperstimulation Syndrome - metabolism
Ovarian Hyperstimulation Syndrome - physiopathology
Oxidoreductases Acting on CH-NH Group Donors - genetics
Polymorphism, Genetic
Prothrombin - genetics
Risk Factors
Severity of Illness Index
Sterility. Assisted procreation
Thrombosis - etiology
Thrombosis - genetics
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Summary:BACKGROUND: The aim of this study was to investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients. Additionally, we also assessed whether any abnormalities in the haemostatic system were more frequent in women with a past history of OHSS. METHODS: A pilot study was carried out involving OHSS patients and matched IVF patients. Homeostasis model assessment (HOMA) of insulin sensitivity was calculated. The main outcome measures were: insulin sensitivity, coagulation anomalies, factor V Leiden mutations, methylene tetrahydrofolate reductase (MTHFR) polymorphism and prothrombin gene mutation, protein C and protein S deficiency. RESULTS: No increased incidence in hyperinsulism nor in abnormalities of the haemostatic system were observed. CONCLUSIONS: This pilot study does not provide evidence for an increased prevalence of hyperinsulinism among women who have developed OHSS in the past.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/17.8.1994