Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 48 Japanese patients with autoimmune thrombocytopenic purpura (AITP), including 40 chronic idiopathic thrombocytopenic purpura (ITP) and eight secondary AITP, were investigated. H. pylori infection...

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Bibliographic Details
Published in:British journal of haematology 2002-08, Vol.118 (2), p.584-588
Main Authors: Kohda, Kyuhei, Kuga, Takashi, Kogawa, Katsuhisa, Kanisawa, Yuuji, Koike, Kazuhiko, Kuroiwa, Ganji, Hirayama, Yasuo, Sato, Yasushi, Niitsu, Yoshiro
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Adult
Aged
Aged, 80 and over
Amoxicillin - therapeutic use
Anti-Bacterial Agents - therapeutic use
Blood Platelets - drug effects
Clarithromycin - therapeutic use
Drug Therapy, Combination
eradication therapy
Female
Helicobacter Infections - blood
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter pylori
Hematology
Humans
idiopathic thrombocytopenic purpura
Immunosuppressive Agents - therapeutic use
Lansoprazole
Male
Middle Aged
Omeprazole - analogs & derivatives
Omeprazole - therapeutic use
Penicillins - therapeutic use
Platelet Count
Purpura, Thrombocytopenic, Idiopathic - blood
Purpura, Thrombocytopenic, Idiopathic - microbiology
secondary autoimmune thrombocytopenic purpura
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Summary:The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 48 Japanese patients with autoimmune thrombocytopenic purpura (AITP), including 40 chronic idiopathic thrombocytopenic purpura (ITP) and eight secondary AITP, were investigated. H. pylori infection was found in 25 ITP patients (62·5%) and in two secondary AITP (25%). H.pylori eradication was obtained in 19 of 19 infected ITP patients (100%), who were not in remission (platelets
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03612.x