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3-Aryl pyrazolo[4,3- d]pyrimidine derivatives : nonpeptide CRF-1 antagonists
The synthesis of a series of 3-aryl pyrazolo[4,3- d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated. The synthesis of a series...
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Published in: | Bioorganic & medicinal chemistry letters 2002-08, Vol.12 (16), p.2133-2136 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The synthesis of a series of 3-aryl pyrazolo[4,3-
d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.
The synthesis of a series of 3-aryl pyrazolo[4,3-
d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(02)00358-X |