Role of ionic transport in regulation of hemoglobin affinity for oxygen in diabetes mellitus

The rate of Na(+)/H(+) exchange is increased by 24%, activities of Ca-dependent K+ channels is increased by 13%, and activity of erythrocyte Ca(2+)-ATPase decreased by 17% in patients with diabetes mellitus concomitant with essential hypertension in comparison with patients with essential hypertensi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-04, Vol.133 (4), p.396-398
Main Authors: Maksimova, N V, Nagovitsyn, A V, Maksimov, G V
Format: Article
Language:English
Subjects:
Calcium-Transporting ATPases - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Hemoglobins - metabolism
Humans
Hypertension - blood
Hypertension - complications
Ion Transport
Oxygen - metabolism
Sodium-Hydrogen Exchangers - blood
Spectrum Analysis
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Summary:The rate of Na(+)/H(+) exchange is increased by 24%, activities of Ca-dependent K+ channels is increased by 13%, and activity of erythrocyte Ca(2+)-ATPase decreased by 17% in patients with diabetes mellitus concomitant with essential hypertension in comparison with patients with essential hypertension without disorders of carbohydrate metabolism. Changes in activity of Na(+)/H(+) exchange, Ca-dependent K(+) channels, and erythrocyte Ca(2+)-ATPase and increased oxygen affinity of hemoglobin are due to increased glucose concentration in the plasma and are leveled by olifen.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1016266525531