The effect of high dose atorvastatin therapy on lipids and lipoprotein subfractions in overweight patients with type 2 diabetes

Few data are available on the effects of high dose statin therapy on lipoprotein subfractions in type 2 diabetes. In a double blind randomised placebo-controlled trial we have studied the effects of 80 mg atorvastatin over 8 weeks on LDL, VLDL and HDL subfractions in 40 overweight type 2 diabetes pa...

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Bibliographic Details
Published in:Atherosclerosis 2004-05, Vol.174 (1), p.141-149
Main Authors: Lawrence, J.M, Reid, J, Taylor, G.J, Stirling, C, Reckless, J.P.D
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis of Variance
Apolipoproteins B - drug effects
Apolipoproteins B - metabolism
Atherosclerosis (general aspects, experimental research)
Atorvastatin
Atorvastatin Calcium
Biological and medical sciences
Blood and lymphatic vessels
Body Mass Index
Cardiology. Vascular system
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
HDL
Heptanoic Acids - administration & dosage
Humans
Lipid Metabolism
Lipoprotein subfractions
Lipoproteins - drug effects
Lipoproteins - metabolism
Lipoproteins, LDL - drug effects
Lipoproteins, LDL - metabolism
Lipoproteins, VLDL - drug effects
Lipoproteins, VLDL - metabolism
Male
Medical sciences
Middle Aged
Obesity - complications
Obesity - diagnosis
Obesity - drug therapy
Pyrroles - administration & dosage
Reference Values
Small dense LDL
Statin
Treatment Outcome
VLDL
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Summary:Few data are available on the effects of high dose statin therapy on lipoprotein subfractions in type 2 diabetes. In a double blind randomised placebo-controlled trial we have studied the effects of 80 mg atorvastatin over 8 weeks on LDL, VLDL and HDL subfractions in 40 overweight type 2 diabetes patients. VLDL and LDL subfractions were prepared by density gradient ultracentrifugation. Triglycerides, cholesterol, total protein and phospholipids were measured and mass of subfractions calculated. HDL subfractions were prepared by precipitation. Atorvastatin 80 mg produced significant falls in LDL subfractions (LDL 1 66.2 mg/dl:36.6 mg/dl, LDL 2 118:56.6 mg/dl, LDL 3 36.9:19.9 mg/dl all P
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2004.01.016