The effect of heparin rinse on the biocompatibility of continuous veno-venous hemodiafiltration

The aims of our cross-over randomized study were (1) to assess hemostasis in patients with acute renal failure (ARF) and (2) to determine whether or not the generally recommended heparin rinse of the extracorporeal circuit (ECC) prior to the procedure affects thrombogenicity, complement activation,...

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Bibliographic Details
Published in:International journal of artificial organs 2002-06, Vol.25 (6), p.520-528
Main Authors: Opatrný, Jr, K, Polanská, K, Krouzecký, A, Vít, L, Novák, I, Kasal, E
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - physiopathology
Acute Kidney Injury - therapy
Aged
Complement Activation - drug effects
Critical Illness
Cross-Over Studies
Drug Incompatibility
Female
Fibrinolytic Agents - pharmacology
Hemodiafiltration
Hemodialysis Solutions - pharmacology
Hemostasis - drug effects
Heparin - pharmacology
Humans
Leukocyte Count
Male
Middle Aged
Prospective Studies
Thrombosis - blood
Thrombosis - physiopathology
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Summary:The aims of our cross-over randomized study were (1) to assess hemostasis in patients with acute renal failure (ARF) and (2) to determine whether or not the generally recommended heparin rinse of the extracorporeal circuit (ECC) prior to the procedure affects thrombogenicity, complement activation, and leukocyte count in blood during continuous venovenous hemodiafiltration (CVVHDF). Eleven critically ill ARF patients were treated, in random order, using CVVHDF in postdilution setup following ECC rinse with saline (A) with heparin at a concentration of 2,000 IU/L (10 procedures), (B) with heparin at a concentration of 10,000 IU/L (7 procedures), and (C) without heparin (9 procedures). Except for the rinse, anticoagulation therapy did not differ in individual patients during the procedures. Blood was withdrawn before, and at minutes 15, 60, and 360 invariably at diafilter inlet and outlet. Compared with healthy individuals, patients showed lower blood thrombocyte counts (153 vs 233*10(9)/L, p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880202500606