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Contribution of cholinergic systems to state-dependent modulation of respiratory control
Respiration is altered during different stages of the sleep–wake cycle. We review the contribution of cholinergic systems to this alteration, with particular reference to the role of muscarinic acetylcholine receptors (MAchRs) during rapid eye movement (REM) sleep. Available evidence demonstrates th...
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Published in: | Respiratory physiology & neurobiology 2002-07, Vol.131 (1), p.135-144 |
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container_title | Respiratory physiology & neurobiology |
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creator | Bellingham, Mark C Ireland, Matthew F |
description | Respiration is altered during different stages of the sleep–wake cycle. We review the contribution of cholinergic systems to this alteration, with particular reference to the role of muscarinic acetylcholine receptors (MAchRs) during rapid eye movement (REM) sleep. Available evidence demonstrates that MAchRs have potent excitatory effects on medullary respiratory neurones and respiratory motoneurones, and are likely to contribute to changes in central chemosensitive drive to the respiratory control system. These effects are likely to be most prominent during REM sleep, when cholinergic brainstem neurones show peak activity levels. It is possible that MAchR dysfunction is involved in sleep-disordered breathing, such as obstructive sleep apnea. |
doi_str_mv | 10.1016/S1569-9048(02)00043-5 |
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We review the contribution of cholinergic systems to this alteration, with particular reference to the role of muscarinic acetylcholine receptors (MAchRs) during rapid eye movement (REM) sleep. Available evidence demonstrates that MAchRs have potent excitatory effects on medullary respiratory neurones and respiratory motoneurones, and are likely to contribute to changes in central chemosensitive drive to the respiratory control system. These effects are likely to be most prominent during REM sleep, when cholinergic brainstem neurones show peak activity levels. 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It is possible that MAchR dysfunction is involved in sleep-disordered breathing, such as obstructive sleep apnea.</description><subject>Animals</subject><subject>Apnea, obstructive sleep</subject><subject>Cholinergic Fibers - physiology</subject><subject>Cholinergic system, sleep–wake cycle</subject><subject>Control of breathing, sleep–wake cycle</subject><subject>Humans</subject><subject>Models, Neurological</subject><subject>Receptors, acetylcholine, muscarinic</subject><subject>Receptors, Cholinergic - physiology</subject><subject>Receptors, Muscarinic - physiology</subject><subject>Respiratory Mechanics - physiology</subject><subject>Sleep Stages - physiology</subject><subject>Sleep, sleep–wake cycle, cholinergic system</subject><subject>Wakefulness - physiology</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMorl8_QelJ9FDNNE2TnkQWv0DwoIK3kE2mGmmbNUmF_fd23V08espkeN4Z5iHkGOgFUKgun4FXdV7TUp7R4pxSWrKcb5E9kELmwKHeHusNMiH7MX5SCgIE2yUTKICK8btH3qa-T8HNhuR8n_kmMx--dT2Gd2eyuIgJu5gln8WkE-YW59hb7FPWeTu0ehMKGOcu6OTDIjPLgb49JDuNbiMerd8D8np78zK9zx-f7h6m14-5KYGlXGuGtSxQMLBVKU3FuG5mstBMUIYNaG5KWox9MFBxKVBWtqa8gBmI2lSWHZDT1dx58F8DxqQ6Fw22re7RD1EJkHVZlvUI8hVogo8xYKPmwXU6LBRQtVSqfpWqpS9FC_WrVPExd7JeMMw6tH-ptcMRuFoBOJ757TCoaBz2Bq0LaJKy3v2z4gfdCocc</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Bellingham, Mark C</creator><creator>Ireland, Matthew F</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Contribution of cholinergic systems to state-dependent modulation of respiratory control</title><author>Bellingham, Mark C ; Ireland, Matthew F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-aa3e982e731d648c635afb82a3703ef1a5c4028c61c16587e86d90521b179c6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Apnea, obstructive sleep</topic><topic>Cholinergic Fibers - physiology</topic><topic>Cholinergic system, sleep–wake cycle</topic><topic>Control of breathing, sleep–wake cycle</topic><topic>Humans</topic><topic>Models, Neurological</topic><topic>Receptors, acetylcholine, muscarinic</topic><topic>Receptors, Cholinergic - physiology</topic><topic>Receptors, Muscarinic - physiology</topic><topic>Respiratory Mechanics - physiology</topic><topic>Sleep Stages - physiology</topic><topic>Sleep, sleep–wake cycle, cholinergic system</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellingham, Mark C</creatorcontrib><creatorcontrib>Ireland, Matthew F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellingham, Mark C</au><au>Ireland, Matthew F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of cholinergic systems to state-dependent modulation of respiratory control</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>131</volume><issue>1</issue><spage>135</spage><epage>144</epage><pages>135-144</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Respiration is altered during different stages of the sleep–wake cycle. 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subjects | Animals Apnea, obstructive sleep Cholinergic Fibers - physiology Cholinergic system, sleep–wake cycle Control of breathing, sleep–wake cycle Humans Models, Neurological Receptors, acetylcholine, muscarinic Receptors, Cholinergic - physiology Receptors, Muscarinic - physiology Respiratory Mechanics - physiology Sleep Stages - physiology Sleep, sleep–wake cycle, cholinergic system Wakefulness - physiology |
title | Contribution of cholinergic systems to state-dependent modulation of respiratory control |
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