Contribution of cholinergic systems to state-dependent modulation of respiratory control

Respiration is altered during different stages of the sleep–wake cycle. We review the contribution of cholinergic systems to this alteration, with particular reference to the role of muscarinic acetylcholine receptors (MAchRs) during rapid eye movement (REM) sleep. Available evidence demonstrates th...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2002-07, Vol.131 (1), p.135-144
Main Authors: Bellingham, Mark C, Ireland, Matthew F
Format: Article
Language:English
Subjects:
Animals
Apnea, obstructive sleep
Cholinergic Fibers - physiology
Cholinergic system, sleep–wake cycle
Control of breathing, sleep–wake cycle
Humans
Models, Neurological
Receptors, acetylcholine, muscarinic
Receptors, Cholinergic - physiology
Receptors, Muscarinic - physiology
Respiratory Mechanics - physiology
Sleep Stages - physiology
Sleep, sleep–wake cycle, cholinergic system
Wakefulness - physiology
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Summary:Respiration is altered during different stages of the sleep–wake cycle. We review the contribution of cholinergic systems to this alteration, with particular reference to the role of muscarinic acetylcholine receptors (MAchRs) during rapid eye movement (REM) sleep. Available evidence demonstrates that MAchRs have potent excitatory effects on medullary respiratory neurones and respiratory motoneurones, and are likely to contribute to changes in central chemosensitive drive to the respiratory control system. These effects are likely to be most prominent during REM sleep, when cholinergic brainstem neurones show peak activity levels. It is possible that MAchR dysfunction is involved in sleep-disordered breathing, such as obstructive sleep apnea.
ISSN:1569-9048
1878-1519
DOI:10.1016/S1569-9048(02)00043-5