Chemotherapy with or without radiotherapy in patients with locoregionally recurrent nasopharyngeal carcinoma

Background Treatment of locoregionally recurrent nasopharyngeal carcinoma (NPC) is challenging because of prior radiotherapy, morbidities from disease recurrence, and limited therapeutic options available. Methods A retrospective study of patients with locoregionally recurrent NPC. Result Between Ma...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2002-06, Vol.24 (6), p.549-554
Main Authors: Wong, Zee-Wan, Tan, Eng-Huat, Yap, Swee-Peng, Tan, Terence, Leong, Swan-Swan, Fong, Kam-Weng, Wee, Joseph
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Chemotherapy
Chemotherapy, Adjuvant
Cisplatin - therapeutic use
Disease Progression
Diseases of the upper aerodigestive tract
Ent and stomatology
Female
Fluorouracil - therapeutic use
Humans
locoregional
Male
Medical sciences
Middle Aged
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - radiotherapy
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - radiotherapy
Palliative Care
Pharmacology. Drug treatments
radiotherapy
Radiotherapy Dosage
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
recurrent nasopharyngeal carcinoma
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Treatment of locoregionally recurrent nasopharyngeal carcinoma (NPC) is challenging because of prior radiotherapy, morbidities from disease recurrence, and limited therapeutic options available. Methods A retrospective study of patients with locoregionally recurrent NPC. Result Between March 1994 and December 1999, there were 42 patients; most were Chinese (98%) men (81%) with undifferentiated NPC (86%). A repeat course of radiotherapy was feasible in 20 patients and given concurrently with cisplatin followed by adjuvant cisplatin/5‐fluorouracil (PF) (group 1). The remaining 22 (group 2) received palliative chemotherapy (PF) with a response rate of 50%. Significant morbidities resulted from cranial nerve palsies. The 2‐year progression‐free survival of patients in group 1 was expectedly better (58% vs 38%). Six (14%) developed systemic metastases at 12 months (median) from first recurrence. Conclusion Concurrent chemoradiotherapy for locoregional recurrent NPC seems promising. The morbidity experienced resulted from locoregional disease with few progressing to develop systemic involvement. © 2002 Wiley Periodicals, Inc. Head Neck 24: 549–554, 2002
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.10098