Oligodendrocytes as providers of growth factors

Glial cells recently are being appreciated as supporters of brain neurons. This review addresses their role as growth factor providers. While the function of astrocytes in this capacity is known, new data indicate that oligodendrocytes, the myelinating cells of the brain, exhibit similar abilities....

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Bibliographic Details
Published in:Journal of neuroscience research 2002-06, Vol.68 (6), p.647-654
Main Authors: Du, Yangzhou, Dreyfus, Cheryl F.
Format: Article
Language:English
Subjects:
Animals
Astrocytes - metabolism
Epidermal Growth Factor - metabolism
Fibroblast Growth Factor 9
Fibroblast Growth Factors - metabolism
glia
Glial Cell Line-Derived Neurotrophic Factor
Growth Substances - metabolism
Growth Substances - secretion
Heparin-binding EGF-like Growth Factor
Insulin-Like Growth Factor I - metabolism
Intercellular Signaling Peptides and Proteins
Nerve Growth Factors - metabolism
Nerve Tissue Proteins - metabolism
neuregulins
Neuregulins - metabolism
neurotrophins
Oligodendroglia - metabolism
Transforming Growth Factor beta - metabolism
trophic effects of oligodendrocytes
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Summary:Glial cells recently are being appreciated as supporters of brain neurons. This review addresses their role as growth factor providers. While the function of astrocytes in this capacity is known, new data indicate that oligodendrocytes, the myelinating cells of the brain, exhibit similar abilities. Oligodendrocytes provide trophic signals to nearby neurons and synthesize defined growth factors. Expression of growth factors is influenced by neural signals. The review summarizes these roles and their implications in brain function. © 2002 Wiley‐Liss, Inc.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.10245