HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury

Background: Blunt abdominal trauma that leads to hemorrhagic shock and cardiac arrest is almost always fatal in the prehospital setting. The current study investigated whether a hemoglobin-based oxygen carrier (HBOC-201) could maintain organ viability during an exsanguinating liver injury and allow...

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Bibliographic Details
Published in:Resuscitation 2002-07, Vol.54 (1), p.77-87
Main Authors: Katz, Laurence M., Manning, James E., McCurdy, Shane, Pearce, L.Bruce, Gawryl, Maria S., Wang, Yuanfan, Brown, Chad
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood Pressure
Blood Substitutes - administration & dosage
Blood Substitutes - therapeutic use
Blood Volume
Disease Models, Animal
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Fluid therapy
Hemoglobins - therapeutic use
Hemorrhage
Hydroxyethyl Starch Derivatives - administration & dosage
Intensive care medicine
Liver - injuries
Liver - physiopathology
Liver - surgery
Medical sciences
Outcome
Resuscitation
Resuscitation - methods
Shock
Shock, Hemorrhagic - therapy
Survival Analysis
Swine
Trauma
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Summary:Background: Blunt abdominal trauma that leads to hemorrhagic shock and cardiac arrest is almost always fatal in the prehospital setting. The current study investigated whether a hemoglobin-based oxygen carrier (HBOC-201) could maintain organ viability during an exsanguinating liver injury and allow for prolonged survival. This hypothesis was tested in a large animal model that simulated blunt abdominal trauma with major organ injury. Methods: Swine underwent a liver crush, laceration and 50 ml/kg initial blood loss. The liver bled at 3 ml/kg per min during the resuscitation phase. No fluid (NF=6), hetastarch (HES=8), or HBOC-201 (HBOC=8) was given during the resuscitation phase. Swine alive 60 min after the initial injury underwent liver repair and 96 h observation. Results: All HBOC swine survived 60 min versus none of the NF or HES swine ( P
ISSN:0300-9572
1873-1570
DOI:10.1016/S0300-9572(02)00053-9