Human herpesvirus type 8 infections among solid organ transplant recipients

: Human herpes virus 8 (HHV‐8) is known to be associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a form of Castleman's disease. Recently, it has also been shown to be associated with acute bone marrow failure in transplant patients. While, the full spectrum of clini...

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Bibliographic Details
Published in:Pediatric transplantation 2002-06, Vol.6 (3), p.187-192
Main Author: Allen, Upton D.
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
Graft Rejection - etiology
Herpesviridae Infections - complications
Herpesviridae Infections - diagnosis
Herpesviridae Infections - drug therapy
Herpesviridae Infections - epidemiology
Herpesvirus 8, Human
human herpesvirus type 8
Human viral diseases
Humans
Infectious diseases
Kaposi's sarcoma
Medical sciences
Organ Transplantation
Pediatrics
Postoperative Complications - virology
transplantation
Viral diseases
Viral diseases of the nervous system
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Description
Summary:: Human herpes virus 8 (HHV‐8) is known to be associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a form of Castleman's disease. Recently, it has also been shown to be associated with acute bone marrow failure in transplant patients. While, the full spectrum of clinical manifestations due to HHV‐8 is yet to be defined in transplant recipients, it is known to cause post‐transplant KS as a result of primary as well as secondary infection. This review will discuss the possible role of HHV‐8 as a cause of disease in solid organ transplant recipients by focussing on important issues, including the biology of the virus, epidemiology, clinical manifestations, laboratory diagnosis and treatment, followed by a discussion of issues of relevance to the pediatric transplant recipient.
ISSN:1397-3142
1399-3046
DOI:10.1034/j.1399-3046.2002.02006.x