Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favourably with day 5 blastocyst transfer

BACKGROUND: The respective advantages of day 3 and day 5 embryo transfer are a matter of debate. Previous comparisons did not include pronuclear stage zygote scoring and cumulative success rates (fresh and cryopreserved embryos). METHODS: Patients were randomized prospectively for day 3 or day 5 emb...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2002-07, Vol.17 (7), p.1852-1855
Main Authors: Rienzi, Laura, Ubaldi, Filippo, Iacobelli, Marcello, Ferrero, Susanna, Minasi, Maria Giulia, Martinez, Francisco, Tesarik, Jan, Greco, Ermanno
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Blastocyst
blastocyst transfer
Cleavage Stage, Ovum
Cryopreservation
Delivery, Obstetric
Embryo Implantation
embryo quality evaluation
Embryo Transfer
embryo transfer policy
Female
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Oocytes
Parturition
Pregnancy
Pregnancy Rate
pronuclear scoring
Sterility. Assisted procreation
Time Factors
Tissue and Organ Harvesting
Zygote Intrafallopian Transfer
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Summary:BACKGROUND: The respective advantages of day 3 and day 5 embryo transfer are a matter of debate. Previous comparisons did not include pronuclear stage zygote scoring and cumulative success rates (fresh and cryopreserved embryos). METHODS: Patients were randomized prospectively for day 3 or day 5 embryo transfer. Day 3 embryos were selected for transfer and cryopreservation by using combined evaluation at the pronuclear and cleavage stages. RESULTS: There was no difference between day 3 and day 5 fresh embryo transfers as to the rates of pregnancy (58 versus 62%), clinical pregnancy (56 versus 58%), delivery (50 versus 48%), implantation (35 versus 38%) and birth (33 versus 36%) rates. The corresponding values for cryopreserved embryo transfers were also similar. However, day 3 embryo transfer compared favourably with day 5 transfer when the pregnancy (90 versus 66%), clinical pregnancy (85 versus 62%) and delivery (77 versus 52%) rates were calculated per oocyte recovery attempt. CONCLUSIONS: With a selected population of good prognosis patients and our embryo selection criteria, the implantation potential of day 3 and day 5 embryos is equal. Per oocyte recovery attempt, day 3 transfer is more clinically efficient than day 5 transfer, but at least one transfer of cryopreserved embryos is necessary to manifest this superiority.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/17.7.1852