Complete Genome Sequences and Phylogenetic Analysis of West Nile Virus Strains Isolated from the United States, Europe, and the Middle East

The complete nucleotide sequences of eight West Nile (WN) virus strains (Egypt 1951, Romania 1996-MQ, Italy 1998-equine, New York 1999-equine, MD 2000-crow265, NJ 2000MQ5488, NY 2000-grouse3282, and NY 2000-crow3356) were determined. Phylogenetic trees were constructed from the aligned nucleotide se...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2002-06, Vol.298 (1), p.96-105
Main Authors: Lanciotti, Robert S., Ebel, Gregory D., Deubel, Vincent, Kerst, Amy J., Murri, Severine, Meyer, Richard, Bowen, Michael, McKinney, Nancy, Morrill, William E., Crabtree, Mary B., Kramer, Laura D., Roehrig, John T.
Format: Article
Language:English
Subjects:
Animals
Europe
flavivirus
Genome, Viral
Humans
Middle East
Molecular Sequence Data
nucleic acid sequence
phylogenetic analysis
Phylogeny
United States
West Nile virus
West Nile virus - classification
West Nile virus - genetics
West Nile virus - isolation & purification
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Summary:The complete nucleotide sequences of eight West Nile (WN) virus strains (Egypt 1951, Romania 1996-MQ, Italy 1998-equine, New York 1999-equine, MD 2000-crow265, NJ 2000MQ5488, NY 2000-grouse3282, and NY 2000-crow3356) were determined. Phylogenetic trees were constructed from the aligned nucleotide sequences of these eight viruses along with all other previously published complete WN virus genome sequences. The phylogenetic trees revealed the presence of two genetic lineages of WN viruses. Lineage 1 WN viruses have been isolated from the northeastern United States, Europe, Israel, Africa, India, Russia, and Australia. Lineage 2 WN viruses have been isolated only in sub-Saharan Africa and Madagascar. Lineage 1 viruses can be further subdivided into three monophyletic clades.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.2002.1449