Effect of Donor Factors on Early Graft Survival in Adult Cadaveric Renal Transplantation

Previous studies of the effect of donor factors on renal transplant outcomes have not tested the role of recipient body mass index, donor/recipient weight ratios and age matching, and other factors. We analyzed 20 309 adult (age 16 or older) recipients having solitary cadaveric renal transplants fro...

Full description

Saved in:
Bibliographic Details
Published in:American journal of transplantation 2002-01, Vol.2 (1), p.68-75
Main Authors: Swanson, S. John, Hypolite, Iman O., Agodoa, Lawrence Y. C., Batty Jr, D. Scott, Hshieh, Paul B., Cruess, David, Kirk, Allan D., Peters, Thomas G., Abbott, Kevin C.
Format: Article
Language:English
Subjects:
Adult
African American donor
Age Factors
Analysis of Variance
Body Mass Index
Body Weight
Cadaver
cadaveric renal transplantation
Creatinine - metabolism
donor
donor death
Female
Follow-Up Studies
Graft Rejection - epidemiology
graft survival
Graft Survival - physiology
Humans
Kidney Transplantation - immunology
Kidney Transplantation - mortality
Kidney Transplantation - physiology
Male
Middle Aged
Multivariate Analysis
recipient weight ratio
Survival Analysis
Time Factors
Tissue Donors - statistics & numerical data
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies of the effect of donor factors on renal transplant outcomes have not tested the role of recipient body mass index, donor/recipient weight ratios and age matching, and other factors. We analyzed 20 309 adult (age 16 or older) recipients having solitary cadaveric renal transplants from adult donors from 1 July 1994 to 30 June 1998 in an historical cohort study (the 2000 United States Renal Data System) of death censored graft loss by the Cox proportional hazards models, which corrected for characteristics thought to affect outcomes. The only independently significant findings in Cox Regression analysis were a high donor/recipient age ratio (≥ 1.10, e.g. a 55‐year‐old donor given to a recipient age 50 years or younger, adjusted hazard ratio (AHR) 3.22, 95% confidence interval (CI) 2.36–4.39) and African American donor kidneys (AHR 1.64, 95% CI, 1.24–2.17). African American recipients and older donors were not at independently increased risk of graft failure in this model. Among donor factors, older donor kidneys given to younger recipients and donor African American kidneys were independently associated with graft loss in recipients of cadaver kidneys. The task for the transplant community should be to find the best means for managing all donor organs without discouraging organ donation.
ISSN:1600-6135
1600-6143
DOI:10.1034/j.1600-6143.2002.020112.x