High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: absence of correlation with hepatitis C virus infection

Hematology Division, Federico II University, Naples, Italy. BACKGROUND AND OBJECTIVES: During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin'...

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Published in:Haematologica (Roma) 2002-07, Vol.87 (7), p.714-718
Main Authors: De Renzo, A, Persico, E, de Marino, F, di Giacomo Russo, G, Notaro, R, di Grazia, C, Picardi, M, Santoro, L, Torella, R, Rotoli, B, Persico, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
B-Lymphocytes - pathology
Biological and medical sciences
Comorbidity
Female
Flaviviridae Infections - complications
Flaviviridae Infections - epidemiology
GB virus C
Hematologic and hematopoietic diseases
Hepacivirus
Hepatitis C - complications
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis, Viral, Human - complications
Hepatitis, Viral, Human - diagnosis
Hepatitis, Viral, Human - epidemiology
Hodgkin Disease - epidemiology
Hodgkin Disease - etiology
Hodgkin Disease - virology
Human viral diseases
Humans
Infectious diseases
Italy - epidemiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoproliferative Disorders - epidemiology
Lymphoproliferative Disorders - etiology
Lymphoproliferative Disorders - virology
Male
Medical sciences
Middle Aged
Prevalence
Viral diseases
Viral hepatitis
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Summary:Hematology Division, Federico II University, Naples, Italy. BACKGROUND AND OBJECTIVES: During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. DESIGN AND METHODS: The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. RESULTS: We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p
ISSN:0390-6078
1592-8721