Neuron Navigator: A Human Gene Family with Homology to unc-53, a Cell Guidance Gene from Caenorhabditis elegans

We have cloned the gene neuron navigator-1 (NAV1), a human homolog of unc-53, a gene involved in axon guidance in Caenorhabditis elegans. Duplications during evolution gave rise to three human homologs located on chromosomes 1q32.1, 11p15.1, and 12q21.1. NAV1 and NAV2 are expressed in the developing...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2002-07, Vol.80 (1), p.21-30
Main Authors: Maes, Tamara, Barceló, Anna, Buesa, Carlos
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Sequence
Animals
Biological and medical sciences
Blotting, Northern
Caenorhabditis elegans - genetics
Caenorhabditis elegans Proteins - genetics
Classical genetics, quantitative genetics, hybrids
Drosophila - genetics
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Microfilament Proteins - genetics
Microtubule-Associated Proteins
Molecular Sequence Data
Multigene Family
Nerve Growth Factors - genetics
Nerve Tissue Proteins - genetics
Organ Specificity
Phylogeny
Sequence Alignment
Synteny
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Summary:We have cloned the gene neuron navigator-1 (NAV1), a human homolog of unc-53, a gene involved in axon guidance in Caenorhabditis elegans. Duplications during evolution gave rise to three human homologs located on chromosomes 1q32.1, 11p15.1, and 12q21.1. NAV1 and NAV2 are expressed in the developing brain. NAV1, NAV2, and NAV3 expression is detected in adult heart, kidney, and brain, respectively. NAV1 encodes a protein lacking, in the aminoterminal part, a CH domain present in the other NAV genes. The first exon of NAV1 arose through an ancient internal duplication of sequences that also gave rise to exon 8 of NAV3 and exon 7 of NAV2. A detailed study of the NAV environment on the different chromosomes reveals incomplete micro-syntheny between the three regions. Through analysis of the phylogenetic relationships for three different gene families in the NAV environment, we reconstructed part of the events that formed these regions.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.2002.6799