The effects of enoxaparin on the reparative processes in experimental osteonecrosis of the femoral head of the rat

The blood supply of one femoral head of 6‐month‐old rats was severed by incising the periosteum of the neck and cutting the ligamentum teres. The rats were killed on the 30th postoperative day and the femoral bones were obtained for semiquantification of the reparative processes in the necrotic head...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2002-03, Vol.110 (3), p.221-228
Main Authors: Norman, D, Miller, Y. (Rambam Medical Center, Issrael), Sabo, E, Misselevich, I, Peskin, B, Zinman, C, Levin, D, Reis, D.N, Boss, J.H
Format: Article
Language:English
Subjects:
animal model of human disease
ANIMAL MODELS
Animals
Biological and medical sciences
BONE DISEASES
Bone Remodeling - drug effects
Bones, joints and connective tissue. Antiinflammatory agents
ENFERMEDADES HUMANAS
ENFERMEDADES OSEAS
Enoxaparin
Enoxaparin - pharmacology
Enoxaparin - therapeutic use
Femur Head - drug effects
Femur Head - pathology
Fibrinolytic Agents - pharmacology
Fibrinolytic Agents - therapeutic use
HEPARIN
HEPARINA
HEPARINE
HUESOS DE LOS MIEMBROS
HUMAN DISEASES
Legg-Calvé-Perthes disease
LIMB BONES
MALADIE DE L'HOMME
Male
Medical sciences
MODELE ANIMAL
MODELOS ANIMALES
OS DES MEMBRES
osteonecrosis
Osteonecrosis - drug therapy
Osteonecrosis - pathology
OSTEOPATHIE
Pharmacology. Drug treatments
RAT
RATA
RATS
Rats, Sprague-Dawley
unfractionated heparin and low-molecular-weight heparin
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Summary:The blood supply of one femoral head of 6‐month‐old rats was severed by incising the periosteum of the neck and cutting the ligamentum teres. The rats were killed on the 30th postoperative day and the femoral bones were obtained for semiquantification of the reparative processes in the necrotic heads. Fourteen rats were treated with enoxaparin and 14 untreated animals served as controls. Statistically, the amounts of necrotic bone in the epiphysis were less, the extent of remodeling of the femoral heads was milder, and the articular cartilage degeneration was slighter in the enoxaparin‐treated than untreated rats. There was no significant difference in the quantities of newly formed bone in femoral heads of treated and untreated rats. These findings are in agreement with the known effects of unfractionated and low‐molecular‐weight heparins which enhance osteoclastic bone resorption and angiogenesis and decrease osteoblastic bone formation. The former activities, operative in minimizing the structural distortion of the femoral head, oppose the crucial event in the pathogenesis of post‐osteonecrotic osteoarthritis.
ISSN:0903-4641
1600-0463
DOI:10.1034/j.1600-0463.2002.100304.x