Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines

Leptin, apart from the regulation of food intake, has been implicated in hematopoiesis, the immune response and angiogenesis. Leptin has been found to be decreased in various hematological malignancies. In the present study leptin was measured in multiple myeloma (MM) patients before and after treat...

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Bibliographic Details
Published in:The International journal of biological markers 2004, Vol.19 (1), p.52-57
Main Authors: ALEXANDRAKIS, M. G, PASSAM, F. H, SFIRIDAKI, A, PAPPA, C. A, MOSCHANDREA, J. A, KANDIDAKI, E, TSIRAKIS, G, KYRIAKOU, D. S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analytical, structural and metabolic biochemistry
beta 2-Microglobulin - blood
Biological and medical sciences
C-Reactive Protein - biosynthesis
Case-Control Studies
Cytokines - metabolism
Female
Fibroblast Growth Factor 2 - blood
Fundamental and applied biological sciences. Psychology
Humans
Inflammation
Interleukin-1 - blood
Investigative techniques, diagnostic techniques (general aspects)
Leptin - blood
Male
Medical sciences
Middle Aged
Multiple Myeloma - blood
Neovascularization, Pathologic
Vascular Endothelial Growth Factor A - blood
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Summary:Leptin, apart from the regulation of food intake, has been implicated in hematopoiesis, the immune response and angiogenesis. Leptin has been found to be decreased in various hematological malignancies. In the present study leptin was measured in multiple myeloma (MM) patients before and after treatment and correlated with other angiogenic molecules and markers of disease activity. Serum leptin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), interleukin-1 beta (IL-1beta), beta 2 microglobulin (beta2M) and C-reactive protein (CRP) were measured in 62 newly diagnosed MM patients, 22 of whom obtaining disease stabilization after treatment. The same parameters were measured in 20 healthy controls. Disease stage was defined according to the Durie-Salmon criteria. Leptin, VEGF, b-FGF, IL-1beta, and beta2M were significantly higher in newly diagnosed MM patients than in controls (p
ISSN:0393-6155
1724-6008
1724-6008
DOI:10.1177/172460080401900107