Procalcitonin and the early diagnosis of infective endocarditis

Variability in the clinical presentation of infective endocarditis (IE) makes the diagnosis a clinical challenge. We hypothesized that serum procalcitonin, a marker of systemic bacterial infection, might be helpful in its diagnosis. We conducted a prospective cohort study in 67 consecutive patients...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-04, Vol.109 (14), p.1707-1710
Main Authors: MUELLER, Christian, HUBER, Peter, LAIFER, Gerd, MUELLER, Beat, PERRUCHOUD, André P
Format: Article
Language:English
Subjects:
Adult
Aged
Area Under Curve
Biological and medical sciences
Biomarkers
Blood and lymphatic vessels
C-Reactive Protein - analysis
Calcitonin - blood
Calcitonin Gene-Related Peptide
Cardiology. Vascular system
Cohort Studies
Comorbidity
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Early Diagnosis
Endocarditis, Bacterial - blood
Endocarditis, Bacterial - diagnosis
Endocarditis, Bacterial - microbiology
Female
Humans
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Prospective Studies
Protein Precursors - blood
Risk Factors
ROC Curve
Sensitivity and Specificity
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Summary:Variability in the clinical presentation of infective endocarditis (IE) makes the diagnosis a clinical challenge. We hypothesized that serum procalcitonin, a marker of systemic bacterial infection, might be helpful in its diagnosis. We conducted a prospective cohort study in 67 consecutive patients admitted to the hospital with the suspicion of IE or in whom the suspicion arose during the hospital course. IE was diagnosed by an interdisciplinary team that included an infectious disease specialist and a cardiologist who applied the Duke criteria. IE was confirmed in 21 patients. Procalcitonin was significantly higher in patients with IE (median 6.56 ng/mL) than in those with other final diagnoses (median 0.44 ng/mL, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000126281.52345.52