Effects of Growth Hormone (GH) Replacement Therapy on Low-Density Lipoprotein Apolipoprotein B100 Kinetics in Adult Patients with GH Deficiency: A Stable Isotope Study

GH replacement therapy has been shown to improve the dyslipidemic condition in a substantial proportion of patients with adult GH deficiency. The mechanisms are not yet fully elucidated. Low-density lipoprotein (LDL) apolipoprotein B100 (apoB) formation and catabolism are important determinants of p...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2004-04, Vol.89 (4), p.1801-1807
Main Authors: Christ, E. R, Cummings, M. H, Jackson, N, Stolinski, M, Lumb, P. J, Wierzbicki, A. S, Sönksen, P. H, Russell-Jones, D. L, Umpleby, A. M
Format: Article
Language:English
Subjects:
Apolipoprotein B-100
Apolipoproteins B - blood
Biological and medical sciences
Body Composition
Carbon Isotopes
Double-Blind Method
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Glycated Hemoglobin A - metabolism
Growth Hormone - therapeutic use
Hormone Replacement Therapy
Human Growth Hormone - blood
Human Growth Hormone - deficiency
Humans
Insulin - blood
Insulin-Like Growth Factor I - metabolism
Kinetics
Lipids - blood
Lipoproteins, LDL - blood
Male
Medical sciences
Metabolism, Inborn Errors - blood
Metabolism, Inborn Errors - drug therapy
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:GH replacement therapy has been shown to improve the dyslipidemic condition in a substantial proportion of patients with adult GH deficiency. The mechanisms are not yet fully elucidated. Low-density lipoprotein (LDL) apolipoprotein B100 (apoB) formation and catabolism are important determinants of plasma cholesterol concentrations. This study examined the effect of GH replacement therapy on LDL apoB metabolism using a stable isotope turnover technique. LDL apoB kinetics was determined in 13 adult patients with GH deficiency before and after 3 months GH/placebo treatment in a randomized, double-blind, placebo-controlled study. LDL apoB 13C-leucine enrichment was determined by isotope-ratio mass spectrometry. Plasma volume was assessed by standardized radionuclide dilution technique. GH replacement therapy significantly decreased LDL cholesterol, LDL apoB concentrations, and LDL apoB pool size compared with placebo. Compared with baseline, GH replacement therapy resulted in a significant increase in plasma volume and fractional catabolic rate, whereas LDL formation rate remained unchanged. LDL lipid content did not significantly change after GH and placebo. This study suggests that short-term GH replacement therapy decreases the LDL apoB pool by increasing removal of LDL particles without changing LDL composition or LDL apoB production rate. In addition, it is possible that the beneficial effects of GH on the cardiovascular system contribute to these findings.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2003-031474