Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma

The quest for prognostic molecular markers in prostatic carcinoma is still in progress. Many proteins have already been screened by immunohistochemistry with the aim to find the most reliable indicator of progressive disease. In this study, we evaluated the expression of pRb2/p130, p107, p27(kip1),...

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Published in:Clinical cancer research 2002-06, Vol.8 (6), p.1808-1815
Main Authors: Claudio, Pier Paolo, Zamparelli, Alessandra, Garcia, Fernando U, Claudio, Luigi, Ammirati, Giuseppe, Farina, Antonio, Bovicelli, Alessandro, Russo, Giuseppe, Giordano, Giovan Giacomo, McGinnis, David E, Giordano, Antonio, Cardi, Gaetano
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Biomarkers, Tumor - metabolism
Cell Cycle Proteins - metabolism
Cyclin-Dependent Kinase Inhibitor p27
Humans
Immunoenzyme Techniques
Ki-67 Antigen - metabolism
Male
Middle Aged
Nuclear Proteins - metabolism
Phosphoproteins - metabolism
Prognosis
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Proteins
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
Retinoblastoma-Like Protein p107
Retinoblastoma-Like Protein p130
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
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Summary:The quest for prognostic molecular markers in prostatic carcinoma is still in progress. Many proteins have already been screened by immunohistochemistry with the aim to find the most reliable indicator of progressive disease. In this study, we evaluated the expression of pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) by immunohistochemistry in 24 prostate carcinomas compared with the paired expression of normal prostates. Expression of the different proteins in normal and pathological specimens was evaluated by the Wilcoxon test. A matrix of correlation (Spearman coefficient) was used to evaluate the possible association in expression among the different proteins. Logistic regression analysis was used to test the multivariable prognostic value of the levels of protein expression for the probability of disease development. p53 and Ki-67 (MIB-1) showed a higher expression in cancer than in normal tissue (P = 0.006 and
ISSN:1078-0432
1557-3265