ANTISCHISTOSOMAL BIOACTIVITY OF ISOFLAVONOIDS FROM MILLETTIA THONNINGII (LEGUMINOSAE)

Extracts of the seeds of the leguminous tree Millettia thonningii are molluscicidal and schistosomicidal and contain a mixture of isoflavonoids and 3-phenylcoumarins. Robustic acid and a pure mixture of alpinumisoflavone and dimethylalpinumisoflavone, as characterized by nuclear magnetic resonance,...

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Bibliographic Details
Published in:	The Journal of parasitology 2002-02, Vol.88 (1), p.163-170
Main Authors:	Lyddiard, J. R A, Whitfield, P. J, Bartlett, A
Format:	Article
Language:	eng
Subjects:	Animals Anthelmintics - pharmacology Bioassays Biodegradation Biological activity Biological and medical sciences Cercaria Cercariae Chromatography Dichloromethane Eggs Electron transport Electron Transport - drug effects Electrons Energy metabolism Ethanol Fabaceae - chemistry Female Flavonoids - chemistry Flavonoids - pharmacology General pharmacology Imaging techniques Isoflavones - chemistry Isoflavones - pharmacology Isoflavonoids Medical sciences Metabolism Mice Miracidia Mitochondria Mitochondria, Liver - drug effects Mixtures Mode of action Mollusks Motility Movement - drug effects NMR Nuclear magnetic resonance Parasitic Sensitivity Tests Parasitology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Rats Schistosoma mansoni - drug effects Schistosoma mansoni - growth & development Schistosoma mansoni - physiology Schistosomiasis mansoni - parasitology Seeds Seeds - chemistry Swimming THERAPEUTICS-DIAGNOSTICS Tropical diseases
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Summary:	Extracts of the seeds of the leguminous tree Millettia thonningii are molluscicidal and schistosomicidal and contain a mixture of isoflavonoids and 3-phenylcoumarins. Robustic acid and a pure mixture of alpinumisoflavone and dimethylalpinumisoflavone, as characterized by nuclear magnetic resonance, were isolated from a dichloromethane extract. The bioactivity of these compounds against Schistosoma mansoni miracidia, cercariae, and adult worms was tested in vitro. Both robustic acid and the alpinumisoflavone mixture killed cercariae and adult schistosomes in vitro. At sublethal concentrations of the isoflavonoids, reductions in miracidial motility were measured using a video-imaging technique. The inhibition of mitochondrial electron transport at site I by the isolated isoflavonoids was also investigated. The results suggest that robustic acid and at least 1 alpinumisoflavone compound from the dichloromethane extract of the seeds of M. thonningii are responsible for some of the observed bioactivity of this extract against schistosomes.
ISSN:	0022-3395 1937-2345