Enzymatic Behavior by Intercalating Molecules in a Template-Directed Ligation Reaction

Molecular midwifery: A nucleic acid intercalating molecule, proflavine (represented by blue lines), increases the coupling rate of short oligonucleotides in a template‐directed synthesis by three orders of magnitude. Several proflavine molecules act cooperatively to function as a concentration‐depen...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2004-04, Vol.43 (15), p.2004-2008
Main Authors: Jain, Swapan S., Anet, Frank A. L., Stahle, Christopher J., Hud, Nicholas V.
Format: Article
Language:English
Subjects:
chemical ligation
DNA - biosynthesis
DNA - genetics
Intercalating Agents - chemistry
Intercalating Agents - metabolism
intercalations
Models, Molecular
Molecular Structure
nucleic acids
Proflavine - chemistry
Proflavine - metabolism
self-replication
template synthesis
Templates, Genetic
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Summary:Molecular midwifery: A nucleic acid intercalating molecule, proflavine (represented by blue lines), increases the coupling rate of short oligonucleotides in a template‐directed synthesis by three orders of magnitude. Several proflavine molecules act cooperatively to function as a concentration‐dependent multimolecular “enzyme”.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353155