Molecular Characterization of Mutations in Patients with Benign and Aggressive Recurrent Respiratory Papillomatosis: A Preliminary Study

This study was performed to determine whether genetic polymorphisms within the human papillomavirus (HPV) can predict the disease course in patients with recurrent respiratory papillomatosis. The HPV type and genomic variations were determined by comparing the sample sequence to a prototypical HPV i...

Full description

Saved in:
Bibliographic Details
Published in:Annals of otology, rhinology & laryngology rhinology & laryngology, 2004-03, Vol.113 (3), p.180-186
Main Authors: Pou, Anna M., Weems, Justin, Nason, Robert, Deskin, Ronald W., Payne, Deborah A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Child
Child, Preschool
DNA Primers
Female
Genetic Predisposition to Disease
Humans
Infant
Laryngeal Neoplasms - genetics
Male
Medical sciences
Middle Aged
Mutation
Neoplasm Recurrence, Local - genetics
Otorhinolaryngology. Stomatology
Papilloma - genetics
Polymorphism, Genetic
Predictive Value of Tests
Sequence Analysis, DNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was performed to determine whether genetic polymorphisms within the human papillomavirus (HPV) can predict the disease course in patients with recurrent respiratory papillomatosis. The HPV type and genomic variations were determined by comparing the sample sequence to a prototypical HPV in the database of the National Center for Biotechnology Information. The results were correlated with the clinical course. Seven children and 6 adults were studied. Six of the 7 children had aggressive disease associated with HPV type 11. The remaining child had HPV type 6. Five of the 6 adult patients had HPV type 6; 1 had a history of juvenile recurrent respiratory papillomatosis. The remaining adult had an aggressive disease course associated with HPV type 11. The HPV type and specific polymorphisms were conserved over time in serial isolates. The age of onset and medical therapy did not appear to affect the polymorphisms present. Future studies may find that the presence of certain polymorphisms is associated with different geographic locations and possibly with the disease course.
ISSN:0003-4894
1943-572X
DOI:10.1177/000348940411300302