Brain serotonin 1A receptor binding in bulimia nervosa

Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antid...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2004-04, Vol.55 (8), p.871-873
Main Authors: TIIHONEN, Jari, KESKI-RAHKONEN, Anna, LÖPPÖNEN, Mari, MUHONEN, Maria, KAJANDER, Jaana, ALLONEN, Topias, NAGREN, Kjell, HIETALA, Jarmo, RISSANEN, Aila
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - anatomy & histology
Brain - metabolism
Bulimia
Bulimia - metabolism
Case-Control Studies
Eating behavior disorders
Female
Functional Laterality
Humans
Medical sciences
Piperazines - pharmacokinetics
Protein Binding
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Pyridines - pharmacokinetics
Receptor, Serotonin, 5-HT1A - metabolism
Serotonin Antagonists - pharmacokinetics
Statistics, Nonparametric
Tomography, Emission-Computed - methods
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Summary:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant effect of SSRIs is mediated via 5-HT(1A) receptors. The aim of this study was to measure brain 5-HT(1A) receptor binding among nonmedicated patients with bulimia nervosa. Positron emission tomography (PET) with a selective 5-HT(1A) ligand, [11C]WAY-100635, was performed on eight unmedicated patients with bulimia and 10 healthy comparison subjects. The binding potential values were greater in patients than in control subjects in all brain regions studied. The most robust differences were observed in the angular gyrus, the medial prefrontal cortex, and the posterior cingulate cortex. These results suggest that brain 5-HT(1A) receptor binding is increased in several cortical areas in patients with bulimia nervosa during their state of impulsive binge eating.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2003.12.016