Neuronal nitric oxide synthase immunoreactivity in ependymal cells during early postnatal development

Neuronal nitric oxide synthase (nNOS) immunoreactivity was observed in ependymal cell layer of the central canal of spinal cord of neonatal rats (2–20 days old). Neuronal nitric oxide synthase immunoreactivity was present in postnatal day 2 and this immunoreactivity gradually disappeared by postnata...

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Bibliographic Details
Published in:Journal of chemical neuroanatomy 2004-03, Vol.27 (1), p.3-6
Main Authors: Soygüder, Zafer, Karadağ, Hüseyin, Nazli, Mümtaz
Format: Article
Language:English
Subjects:
Aging
Animals
Animals, Newborn
Central canal
Development
Ependyma - cytology
Ependyma - growth & development
Ependyma - metabolism
Ependymal cell
Female
Male
Neuronal nitric oxide synthase
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type I
Rat
Rats
Rats, Wistar
Spinal Cord - metabolism
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Summary:Neuronal nitric oxide synthase (nNOS) immunoreactivity was observed in ependymal cell layer of the central canal of spinal cord of neonatal rats (2–20 days old). Neuronal nitric oxide synthase immunoreactivity was present in postnatal day 2 and this immunoreactivity gradually disappeared by postnatal day 16. The progressive decrease in nNOS staining with the increasing postnatal age may suggest that nNOS staining paralleled the maturation of the central canal and may also suggest that nNOS activity plays a role in the development of the ependymal cells.
ISSN:0891-0618
1873-6300
DOI:10.1016/j.jchemneu.2003.08.004