TNF-α, IL1-β, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis

In order to determine whether TNF-α, IL1-β, GM, and KM genes affect susceptibility to sarcoidosis, coded DNA samples from 278 Caucasian and 219 African-American patients and an equal number of matched controls were genotyped by polymerase chain reaction methods. All genotypes were in Hardy-Weinberg...

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Bibliographic Details
Published in:Human immunology 2002-06, Vol.63 (6), p.485-491
Main Authors: Pandey, Janardan P., Frederick, Margaret
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
Case-Control Studies
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Predisposition to Disease
Humans
Ig allotypes
IL1-β
Immunoglobulin Allotypes - genetics
Immunoglobulin Gm Allotypes - genetics
Interleukin-1 - genetics
polymorphism
Polymorphism, Genetic
sarcoidosis
Sarcoidosis - complications
Sarcoidosis - genetics
Sensitivity and Specificity
TNF-α
Tumor Necrosis Factor-alpha - genetics
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Summary:In order to determine whether TNF-α, IL1-β, GM, and KM genes affect susceptibility to sarcoidosis, coded DNA samples from 278 Caucasian and 219 African-American patients and an equal number of matched controls were genotyped by polymerase chain reaction methods. All genotypes were in Hardy-Weinberg equilibrium. Genotype frequencies in sarcoidosis patients, as a whole, were not significantly different from that in controls. Additional analyses were performed to determine whether patients with and without erythema nodosum had different genetic components. In African-American patients without erythema nodosum, the distribution of KM genotypes was significantly different from that in controls: compared to controls, the frequency of KM1 homozygotes was increased in patients (6.5% versus 13.0%, p = 0.01; odds ratio = 2.56). As KM genes have been reported to be associated with immune responsiveness to several pathogens, these results may be relevant to the etiology of sarcoidosis.
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(02)00399-3