High incidence of parvovirus B19 DNA in synovial tissue of patients with undifferentiated mono- and oligoarthritis

A common problem in rheumatological practice is inflammatory joint disease that cannot be classified. The prognosis of such undifferentiated arthritides is uncertain. The synovial tissue of 41 consecutive patients with various forms of arthritis was tested for the presence of viral DNA in a diagnosi...

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Bibliographic Details
Published in:Clinical rheumatology 2000-01, Vol.19 (4), p.281-286
Main Authors: Stahl, H D, Seidl, B, Hubner, B, Altrichter, S, Pfeiffer, R, Pustowoit, B, Liebert, U G, Hofmann, J, von Salis-Soglio, G, Emmrich, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Viral - analysis
Arthritis
Arthritis - classification
Arthritis - immunology
Arthritis - virology
Base Sequence
Borrelia burgdorferi Group
Cercopithecus aethiops
Child
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus - immunology
Deoxyribonucleic acid
DNA
DNA, Viral - analysis
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
HeLa Cells - virology
Herpes simplex
Herpes viruses
Humans
Incidence
Joint diseases
Lyme Disease
Middle Aged
Molecular Sequence Data
Parvovirus - genetics
Parvoviruses
Polymerase Chain Reaction
RNA viruses
RNA, Viral - analysis
Rubella virus - genetics
Rubella virus - immunology
Simplexvirus - genetics
Simplexvirus - immunology
Synovial Membrane - virology
Vero Cells - virology
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Description
Summary:A common problem in rheumatological practice is inflammatory joint disease that cannot be classified. The prognosis of such undifferentiated arthritides is uncertain. The synovial tissue of 41 consecutive patients with various forms of arthritis was tested for the presence of viral DNA in a diagnosis-unaware fashion, using the polymerase chain reaction (PCR). Of all tested viruses, cytomegalovirus and parvovirus B19 were positive (each in 10 patients, two double-positives), whereas herpes simplex virus was positive in two patients. Rubella virus RNA was detected in three specimens. When the positivity for viral material was analysed in terms of distribution among the various diagnostic groups, it became evident that five out of 10 parvovirus B 19-positive patients belonged to the undifferentiated arthritis group, whereas cytomegalovirus-positive patients were spread among all diagnostic groups. This indicates the possibility of a new diagnostic category of undifferentiated mono- and oligoarthritis, which can be identified by the presence of parvovirus B19 DNA in synovial tissue.
ISSN:0770-3198
1434-9949
DOI:10.1007/s100670070046