nalyot, a Mutation of the Drosophila Myb-Related Adf1 Transcription Factor, Disrupts Synapse Formation and Olfactory Memory

nalyot ( nal) is a novel olfactory memory mutant of Drosophila, encoding Adf1, a myb-related transcription factor. Following extended training sessions, Adf1 mutants show normal early memory but defective long-term memory. Adf1 shows widespread spatiotemporal expression, yet mutant alleles reveal no...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2000-07, Vol.27 (1), p.145-158
Main Authors: DeZazzo, James, Sandstrom, David, de Belle, Steve, Velinzon, Klara, Smith, Patrick, Grady, Lori, DelVecchio, Maria, Ramaswami, Mani, Tully, Tim
Format: Article
Language:English
Subjects:
Activating Transcription Factor 4
Adf1 gene
Alleles
Animals
Blotting, Northern
Blotting, Western
Conditioning, Classical - physiology
dCREB2 gene
DNA Probes
Drosophila
Drosophila Proteins
Electrophysiology
Embryo, Nonmammalian
Gene Expression Regulation - physiology
Genes, myb - genetics
Insect Proteins - biosynthesis
Insect Proteins - genetics
Larva
Leucine Zippers
Memory - physiology
Mutation - genetics
Mutation - physiology
Myb protein
nalyot (nal) gene
Nervous System - growth & development
Neuromuscular Junction - physiology
Presynaptic Terminals - metabolism
Smell - genetics
Smell - physiology
Synapses - physiology
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transcription Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:nalyot ( nal) is a novel olfactory memory mutant of Drosophila, encoding Adf1, a myb-related transcription factor. Following extended training sessions, Adf1 mutants show normal early memory but defective long-term memory. Adf1 shows widespread spatiotemporal expression, yet mutant alleles reveal no discernible disruptions in gross morphology of the nervous system. Studies at the larval neuromuscular junction, however, reveal a role for Adf1 in the modulation of synaptic growth—in contrast to the role established for dCREB2 in the control of synaptic function ( Davis et al. 1996). These findings suggest that Adf1 and dCREB2 regulate distinct transcriptional cascades involved in terminal stages of synapse maturation. More generally, Adf1 provides a novel link between molecular mechanisms of developmental and behavioral plasticity.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)00016-7